Research of the influence of Melanizol pessaries on background of “chemical” vaginitis in rats

The aim. to study the therapeutic influence of new pessaries Melanizol based on metronidazole and tea tree oil background model “chemical” vaginitis in female rats.
 Materials methods. effect was studied rats "chemical" with using argentum nitrate, which provokes not burdened by infection. Against vaginitis, general condition animals, dynamics body weight, morphological composition peripheral blood erythrocyte sedimentation rate (ESR), pH, biochemical parameters (total protein, ALT glucose), temperature vagina rats, macroscopically assessed changes vaginal mucosa (VM) were studied.
 Results discussion. pathology a shift indicators observed. Pessaries at dose 21 mg/kg make experimental caused as indicated restoration VM state, reduced number leukocytes, restored percentage leukocyte formula, amount total protein cytolytic enzyme serum contents, indicates anti-inflammatory cytoprotective agent. recovery temperature, pH glucose contents also observed, normalization homeostasis animals. According these effects, superior reference drug "Gravagin" 30 inferior Hippophaes oleum (HOP) 17.64 mg/kg.
 Conclusions. has been proven. investigated are promising for treatment non-specific require further research this direction